🌿  Natural Origin

Derived from wood by acid hydrolysis. Not metabolised or absorbed by the intestine — purely local action within the GI tract.

✔  Broad-Spectrum Sorption

Variable pore size enables sorption of substances ranging from low molecular weight gases and heavy metals to complex microorganisms.

✔  Selective Activity

High affinity to pathogenic microorganisms and toxins. Does not affect commensal gut flora — no impact on healthy intestinal microbiome.

✔  Universal Indication

Effective across all common causes of acute diarrhoea: bacterial infection, viral gastroenteritis, food poisoning, food allergy, and drug side effects.

Sorption Capacity vs Activated Charcoal

Lignin Hydrolyzed (Filtrum®) vs Activated Charcoal across molecular weight spectrum

Safety confirmed in animal studies (white rats, n=6–10 per group, 10 days administration): 

✔  Filtrum®: No visual or morphological changes to mucous coat of stomach or intestine after 10 days.

✔  Activated Charcoal: Inflammatory reaction developed in mucous coat of GI tract after 10 days — edema of submucous layer, chronic jejunitis.

Filtrum® is indicated for the management of acute diarrhoea of various causes:

·         Intestinal infection (Acute Enteric Infection) — including food poisoning and Traveller’s diarrhoea

·         Food intolerance and food allergy

Key Conclusions Across All Studies:

Study 1 (Uchaykin et al., 2002): Filtrum® + Furazolidone achieved diarrhoea resolution in 75% of children by Day 3 vs 35% with Furazolidone alone. Complete resolution (100%) by Day 5 in the Filtrum® group vs Day 7–8 with Furazolidone monotherapy. Infectious toxicosis resolved in 90% by Day 3 vs 50% in the control group.

Study 2 (Luchev et al., 2001): Average diarrhoea duration 1.05 ± 0.05 days (SoC + Filtrum®) vs 2.43 ± 0.22 days (SoC alone) — 57% faster resolution (p < 0.01). All four core symptoms — fever, diarrhoea, abdominal pain, atony/anorexia — resolved significantly faster with Filtrum® (p < 0.01 for all).

Study 3 (Novokshenov et al., 2009): Stool normalisation by Day 3 in 80% of patients (SoC + Filtrum®) vs 33.3% (SoC alone) in viral AEI in children aged 3–13. No adverse events occurred.

Filtrum® is the only treatment effective across all AEI causes (bacterial, viral, and other including parasites and mycotoxins) — can be used as monotherapy in mild forms or in combination with antibiotics for moderate forms.

Conclusions (Uchaykin et al., 2002):

1.    Filtrum® provides a fast and pronounced anti-diarrhoeal effect and significantly reduces the duration of the acute period of the disease in comparison with conventional Furazolidone therapy of AEIs.

2.    Enterosorption with Filtrum® can be administered as monotherapy in mild forms and in combination with Furazolidone for moderate forms of AEIs in children.

Conclusions (Luchev et al., 2001):

·         Administered with standard of care, Filtrum® showed high clinical efficacy in the treatment of acute enteric infections accompanied by diarrhoea: acute dysentery, gastrointestinal form of salmonellosis, and gastroenteritis form of food poisoning; characterised by reduction in duration of core clinical signs.

·         Filtrum® can be recommended as a drug of choice in mild and moderate forms of AEIs.